Total and differential leucocyte counts in relation to incidence of stroke subtypes and mortality: a prospective cohort study
Open Access
- 3 February 2012
- journal article
- research article
- Published by Wiley in Journal of Internal Medicine
- Vol. 272 (3), 298-304
- https://doi.org/10.1111/j.1365-2796.2012.02526.x
Abstract
Zia E, Melander O, Björkbacka H, Hedblad B, Engström G (Lund University, Malmö; Institute of Clinical Sciences, Lund University, Malmö; Skåne University Hospital, Malmö; and Astra Zeneca R&D, Malmö, Sweden). Total and differential leucocyte counts in relation to incidence of stroke subtypes and mortality: a prospective cohort study. J Intern Med 2012; 272: 298–304. Objectives. Elevated levels of total leucocyte as well as leucocyte subtypes have been associated with increased risk of atherosclerotic disease. Atherosclerosis is an important cause of cerebral infarction, whereas its significance in intracerebral haemorrhage (ICH) is less clear. A small number of prospective studies have revealed the relationship between leucocyte counts and incident stroke, in particular incidence of stroke subtypes. We evaluated the associations between total leucocyte count (TLC) as well as leucocyte subtypes and the incidence of and mortality caused by different stroke subtypes. Design and subjects. Of 28 449 participants from the Malmö Diet and Cancer Study, 26 927 stroke‐free subjects (mean age at screening, 58 ± 8 years) were included in a prospective cohort study. The screening period was between 1991 and 1996. Incidence of stroke, 1‐year mortality and 1‐month case‐fatality rate (CFR) were assessed by linkage to local and national registers. Cox regression analysis was used to assess stroke risk and 1‐year mortality, and 1‐month CFR was assessed by logistic regression analysis. Results. During a follow‐up period of 13.6 ± 3.3 years, 1515 participants had a first‐ever stroke (cerebral infarction, n = 1314; ICH, n = 201). After adjustments for other risk factors, TLC and neutrophil count were significantly associated with increased incidence of cerebral infarction (hazards ratio (HR), 1.4; 95% confidence interval (CI), 1.2–1.7 and 1.3; 95% CI, 1.1–1.5, respectively). There was an inverse association between elevated TLC and incident ICH (HR, 0.7; 95% CI, 0.4–0.99). No associations were found between leucocyte counts and mortality for either stroke subtype. Conclusion. The results suggest that the relationships with inflammation for ischaemic stroke and ICH are different.Keywords
This publication has 23 references indexed in Scilit:
- Association between circulating specific leukocyte types and blood pressure: the Atherosclerosis Risk in Communities (ARIC) studyJournal of the American Society of Hypertension, 2010
- Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6PLoS Medicine, 2009
- Risk Factors for Intracerebral Hemorrhage in a Pooled Prospective StudyStroke, 2007
- Blood Pressure in Relation to the Incidence of Cerebral Infarction and Intracerebral HemorrhageStroke, 2007
- Role of Inflammation in Stroke and AtherothrombosisCerebrovascular Diseases, 2004
- Inflammation in atherosclerosisNature, 2002
- Stroke registry in Malmö, Sweden.Stroke, 1992
- Lobar intracerebral hemorrhageJournal of Neurosurgery, 1992
- The world health organization monica project (monitoring trends and determinants in cardiovascular disease): A major international collaborationJournal of Clinical Epidemiology, 1988
- Leukocyte counts and cerebrovascular diseaseJournal of Chronic Diseases, 1982