Viral dynamics of SARS-CoV-2 variants in vaccinated and unvaccinated individuals
Open Access
- 19 February 2021
- preprint content
- research article
- Published by Cold Spring Harbor Laboratory
Abstract
To test whether acute infection with B.1.1.7 is associated with higher or more sustained nasopharyngeal viral concentrations, we assessed longitudinal PCR tests performed in a cohort of 65 individuals infected with SARS-CoV-2 undergoing daily surveillance testing, including seven infected with B.1.1.7. For individuals infected with B.1.1.7, the mean duration of the proliferation phase was 5.3 days (90% credible interval [2.7, 7.8]), the mean duration of the clearance phase was 8.0 days [6.1, 9.9], and the mean overall duration of infection (proliferation plus clearance) was 13.3 days [10.1, 16.5]. These compare to a mean proliferation phase of 2.0 days [0.7, 3.3], a mean clearance phase of 6.2 days [5.1, 7.1], and a mean duration of infection of 8.2 days [6.5, 9.7] for non-B.1.1.7 virus. The peak viral concentration for B.1.1.7 was 19.0 Ct [15.8, 22.0] compared to 20.2 Ct [19.0, 21.4] for non-B.1.1.7. This converts to 8.5 log10 RNA copies/ml [7.6, 9.4] for B.1.1.7 and 8.2 log10 RNA copies/ml [7.8, 8.5] for non-B.1.1.7. These data offer evidence that SARS-CoV-2 variant B.1.1.7 may cause longer infections with similar peak viral concentration compared to non-B.1.1.7 SARS-CoV-2. This extended duration may contribute to B.1.1.7 SARS-CoV-2’s increased transmissibility.This publication has 28 references indexed in Scilit:
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 VaccineThe New England Journal of Medicine, 2020
- Detection of SARS-CoV-2 RNA by multiplex RT-qPCRPLoS Biology, 2020
- A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiologyNature Microbiology, 2020
- To Interpret the SARS-CoV-2 Test, Consider the Cycle Threshold ValueClinical Infectious Diseases, 2020
- Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodiesCellular & Molecular Immunology, 2020
- Generation of SARS-COV-2 RNA transcript standards for qRT-PCR detection assays v1Published by ZappyLab, Inc. ,2020
- Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020Eurosurveillance, 2020
- Stan: A Probabilistic Programming LanguageJournal of Statistical Software, 2017
- Bayesian Data AnalysisPublished by Taylor & Francis Ltd ,2013
- Computational Many-Particle PhysicsLecture Notes in Physics, 2008