The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
- 20 December 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Gastroenterology & Hepatology
- Vol. 9 (2), 77-87
- https://doi.org/10.1038/nrgastro.2011.215
Abstract
Current standard therapies for pancreatic ductal adenocarcinoma have failed to attenuate the aggressiveness of this disease or confer notable improvements in survival. Previous molecular research into pancreatic cancers, along with advances in sequencing technologies, have identified many altered genes in patients with pancreatic cancer and revealed the marked genetic heterogeneity of individual tumors. Thus, the lack of success of conventional empiric therapy can be partly attributed to the underlying heterogeneity of pancreatic tumors. The genetic alterations that have been detected in pancreatic cancer range from simple mutations at the level of base pairs to complex chromosomal structural changes and rearrangements. The identification of molecular changes that are unique to an individual patient's tumors, and the subsequent development of strategies to target the tumors in a personalized approach to therapeutics, is a necessary advance to improve therapy for patients with this disease.Keywords
This publication has 109 references indexed in Scilit:
- Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherinBritish Journal of Cancer, 2011
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaNature, 2011
- The patterns and dynamics of genomic instability in metastatic pancreatic cancerNature, 2010
- International network of cancer genome projectsNature, 2010
- Signatures of mutation and selection in the cancer genomeNature, 2010
- CD44‐positive cells are responsible for gemcitabine resistance in pancreatic cancer cellsInternational Journal of Cancer, 2009
- Profiling of 95 MicroRNAs in Pancreatic Cancer Cell Lines and Surgical Specimens by Real‐Time PCR AnalysisWorld Journal of Surgery, 2008
- Somatic mutations affect key pathways in lung adenocarcinomaNature, 2008
- Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysNature, 2008
- Expression profiling identifies microRNA signature in pancreatic cancerInternational Journal of Cancer, 2006