Voriconazole versus natamycin as primary treatment in fungal corneal ulcers
- 28 June 2011
- journal article
- research article
- Published by Wiley in Clinical & Experimental Ophthalmology
- Vol. 39 (5), 434-440
- https://doi.org/10.1111/j.1442-9071.2010.02473.x
Abstract
To evaluate the efficacy of topical 1% voriconazole versus 5% natamycin in treatment of fungal corneal ulcers. A prospective, randomized pilot study in a tertiary care hospital. Thirty patients of microbiologically proven fungal keratitis divided randomly in two groups of 15 patients each. Two groups were treated with either 5% natamycin (group A) or 1% voriconazole (group B) topically as a primary treatment for fungal keratitis. The mean size, depth of infiltrate and LogMAR visual acuity at presentation were comparable in both groups (P > 0.05). Patients were followed up for minimum of 10 weeks or till complete resolution of ulcer, whichever was later. Cultures to identify the causative organisms were performed. Time of resolution of the ulcer. Twenty-nine of the total 30 patients showed complete resolution. Average time of resolution and gain in LogMAR visual acuity was 24.3 days and 1.12 in group A and 27.2 days and 0.77 in group B. These were comparable in the two groups (P > 0.05%). Aspergillus spp. (40%) and Curvularia spp. (30.0%) were found to be most common isolates. Topical 1% voriconazole was found to be safe and effective drug in primary management of fungal keratitis, its efficacy matching conventional natamycin. There was no added advantage of using topical 1% voriconazole over topical natamycin as primary treatment in fungal keratitis.Keywords
This publication has 28 references indexed in Scilit:
- Antifungal activity of a new triazole, voriconazole (UK-109,496), compared with three other antifungal agents tested against clinical isolates of filamentous fungiMedical Mycology, 2008
- Fungal Keratitis in LondonCornea, 2007
- The use of voriconazole in the treatment of Aspergillus fumigatus keratitisBritish Journal of Ophthalmology, 2007
- Voriconazole Concentration in Human Aqueous Humor and Plasma during Topical or Combined Topical and Systemic Administration for Fungal KeratitisAntimicrobial Agents and Chemotherapy, 2007
- Risk Factors for Treatment Outcome in Fungal KeratitisOphthalmology, 2006
- Fungal keratitisCurrent Opinion in Opthalmology, 2004
- Pharmacotherapy of fungal eye infectionsExpert Opinion on Pharmacotherapy, 2001
- Incidence of corneal ulceration in Madurai District, South IndiaOphthalmic Epidemiology, 1996
- Causes of suppurative keratitis in Ghana.British Journal of Ophthalmology, 1995
- Suppurative corneal ulceration in BangladeshAustralian and New Zealand Journal of Ophthalmology, 1994