De Novo Asymmetric Bio- and Chemocatalytic Synthesis of Saccharides − Stereoselective Formal O-Glycoside Bond Formation Using Palladium Catalysis

Abstract

A novel integrated bio- and chemocatalytic approach to the de novo catalytic asymmetric synthesis of saccharides has been developed. Acetoxypyranones obtained enantiopure by enzymatic resolution have been shown to undergo highly stereoselective palladium-catalyzed formal O-glycoside bond formation. The combination of these protocols can be applied to the iterative asymmetric catalytic synthesis of saccharides.