Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses
- 1 September 2010
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Vaccines
- Vol. 9 (9), 1095-1107
- https://doi.org/10.1586/erv.10.89
Abstract
The development of novel immune adjuvants is emerging as a significant area of vaccine delivery based on the continued necessity to amplify immune responses to a wide array of new antigens that are poorly immunogenic. This article specifically focuses on the application of nanoparticles and microparticles as vaccine adjuvants. Many investigators are in agreement that the size of the particles is crucial to their adjuvant activities. However, reports on correlating the size of particle-based adjuvants and the resultant immune responses have been conflicting, with investigators on both sides of the fence with impressive data in support of the effectiveness of particles with small sizes (submicron) over those with larger sizes (micron) and vice versa, while other investigators reported data that showed submicron- and micron-sized particles are effective to the same degree as immune adjuvants. We have generated a list of biological, immunological and, more importantly, vaccine formulation parameters that may have contributed to the inconsistency from different studies and made recommendations on future studies attempting to correlate the size of particulate adjuvants and the immune responses induced. The information gathered could lead to strategies to optimize the performance of nano-microparticles as immune adjuvants.Keywords
This publication has 106 references indexed in Scilit:
- Towards preserving the immunogenicity of protein antigens carried by nanoparticles while avoiding the cold chainInternational Journal of Pharmaceutics, 2010
- Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticlesJournal of Controlled Release, 2010
- Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugsAdvanced Drug Delivery Reviews, 2009
- Application of nanotechnologies for improved immune response against infectious diseases in the developing worldAdvanced Drug Delivery Reviews, 2009
- A novel vaccine adjuvant for recombinant flu antigensBiologicals, 2009
- Pharmaceutical Aspects of Intranasal Delivery of Vaccines Using Particulate SystemsJournal of Pharmaceutical Sciences, 2009
- Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasomeProceedings of the National Academy of Sciences of the United States of America, 2009
- A Practical Approach to the use of Nanoparticles for Vaccine DeliveryJournal of Pharmaceutical Sciences, 2006
- PEG-PLA Nanoparticles as Carriers for Nasal Vaccine DeliveryJournal of Aerosol Medicine, 2004
- Biodegradable Microspheres in Drug DeliveryCritical Reviews in Therapeutic Drug Carrier Systems, 1995