Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
Open Access
- 22 May 2014
- journal article
- research article
- Published by Hindawi Limited in International Journal of Endocrinology
- Vol. 2014, 1-6
- https://doi.org/10.1155/2014/323407
Abstract
Betatrophin has recently been described as a key hormone to stimulate beta-cell mass expansion in response to insulin resistance and obesity in mice. The finding has generated an interest in the development of antidiabetic drugs with betatrophin as the active component. However, the circulating levels of betatrophin in patients with type 2 diabetes are not well known. Betatrophin concentrations in plasma of 27 type 2 diabetes patients and 18 gender-, age-, and BMI-matched controls were measured. Study participants were characterized with regard to BMI, waist and hip circumference, blood pressure, and fasting plasma blood lipids, creatinine, glucose, HbA1c, and C-peptide. HOMA2 indices were calculated. Betatrophin was 40% higher in patients with type 2 diabetes (versus pg/mL). Betatrophin positively correlated with age in the controls and with HbA1c in the type 2 diabetes patients. All study participants were insulin resistant with mean HOMA2B IR in both groups exceeding 2 and%. Control individuals had impaired fasting glucose concentrations. In this report on betatrophin concentrations in type 2 diabetes and insulin resistance, elevated betatrophin levels were measured in the patients with type 2 diabetes. Future studies are clearly needed to delineate the exact role, if any, of betatrophin in regulating human beta-cell mass.
Keywords
This publication has 17 references indexed in Scilit:
- Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individualsDiabetologia, 2014
- Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetesDiabetologia, 2013
- RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell ProliferationCell, 2013
- β-Cell Mass and Turnover in HumansDiabetes Care, 2012
- Atypical angiopoietin-like protein that regulates ANGPTL3Proceedings of the National Academy of Sciences of the United States of America, 2012
- Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered ApproachDiabetes Care, 2012
- The Association Between IGF-I and Insulin ResistanceDiabetes Care, 2012
- Pancreatic β‐cell mass in European subjects with type 2 diabetesDiabetes, Obesity and Metabolism, 2008
- Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization methodInternational Journal of Cancer, 2004
- Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer ProgramDiabetes Care, 1998