Influenza A Virus N5 Neuraminidase Has an Extended 150-Cavity
Open Access
- 15 August 2011
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 85 (16), 8431-8435
- https://doi.org/10.1128/jvi.00638-11
Abstract
There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.Keywords
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