Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut)
- 8 August 2013
- journal article
- Published by American Society of Hematology in Blood
- Vol. 122 (6), 1087-1088
- https://doi.org/10.1182/blood-2013-04-496844
Abstract
To the editor: Immune responses directed against epitopes derived from the mutated region of nucleophosmin 1 (NPM1) by NPM1 mut -specific CD8(+) cytotoxic T cells (CTLs) might be involved in the rejection of NPM1 mut myeloid leukemic blasts. NPM1 mutations are one of the most frequent molecularThis publication has 10 references indexed in Scilit:
- Donor Lymphocyte Infusion Induces Polyspecific CD8+ T-Cell Responses With Concurrent Molecular Remission in Acute Myeloid Leukemia With NPM1 MutationJournal of Clinical Oncology, 2013
- Autologous T cells on the attack against AMLBlood, 2012
- Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemiaBlood, 2012
- Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNetBlood, 2010
- High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myelomaHaematologica, 2010
- Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98BHaematologica, 2009
- Leukemia-Associated Antigens Are Critical for the Proliferation of Acute Myeloid Leukemia CellsClinical Cancer Research, 2008
- Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid LeukemiaThe New England Journal of Medicine, 2008
- Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignanciesBlood, 2008
- Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal KaryotypeThe New England Journal of Medicine, 2005