Euplectin and Coneuplectin, New Naphthopyrones from the LichenFlavoparmelia euplecta
- 24 November 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 63 (1), 129-131
- https://doi.org/10.1021/np9903245
Abstract
Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also found to contain the known metabolites usnic acid, protocetraric acid, and skyrin.Keywords
This publication has 8 references indexed in Scilit:
- Depsides and Depsidones as Inhibitors of HIV-1 Integrase: Discovery of Novel Inhibitors through 3D Database SearchingJournal of Medicinal Chemistry, 1997
- Identification of Lichen SubstancesPublished by Springer Science and Business Media LLC ,1996
- In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganismsAntimicrobial Agents and Chemotherapy, 1995
- Mechanistic Evaluation of New Plant-Derived Compounds That Inhibit HIV-1 Reverse TranscriptaseJournal of Natural Products, 1995
- Identification of lichen substances by a standardized high-performance liquid chromatographic methodJournal of Chromatography A, 1993
- Substitution of methyl tert.-butyl ether for diethyl ether in the standardized thin-layer chromatographic method for lichen productsJournal of Chromatography A, 1982
- A standard method for analysing lichen substances with thin layer chromatographyHerzogia, 1979
- Improved conditions and new data for identification of lichen products by standardized thin-layer chromatographic methodJournal of Chromatography A, 1972