Immunocompromised Hosts: Cryptococcosis in Solid Organ Transplant Recipients: Current State of the Science
Open Access
- 15 November 2008
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 47 (10), 1321-1327
- https://doi.org/10.1086/592690
Abstract
Cryptococcosis remains a significant opportunistic infection in solid organ transplant recipients. Disease presentation and outcomes may be affected by, among other factors, the use of calcineurin inhibitor immunosuppressive agents. It is being increasingly recognized that rapid reversal of immunosuppression in transplant recipients treated for cryptococcosis incurs the risk of immune reconstitution inflammatory syndrome, which resembles worsening disease or relapse. This review summarizes the current state of knowledge regarding cryptococcosis in transplant recipients and highlights areas where future investigations are needed to further optimize outcomes for these patients.Keywords
This publication has 67 references indexed in Scilit:
- Central Nervous System Cryptococcosis in Solid Organ Transplant Recipients: Clinical Relevance of Abnormal Neuroimaging FindingsTransplantation, 2008
- Major Role for Amphotericin B–Flucytosine Combination in Severe CryptococcosisPLOS ONE, 2008
- Cryptococcal Neuroradiological Lesions Correlate with Severity during Cryptococcal Meningoencephalitis in HIV-Positive Patients in the HAART EraPLOS ONE, 2008
- Calcineurin Inhibitor Agents Interact Synergistically with Antifungal Agents In Vitro against Cryptococcus neoformans Isolates: Correlation with Outcome in Solid Organ Transplant Recipients with CryptococcosisAntimicrobial Agents and Chemotherapy, 2008
- Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycosesEuropean Journal of Clinical Microbiology & Infectious Diseases, 2008
- Pulmonary Cryptococcosis in Solid Organ Transplant Recipients: Clinical Relevance of Serum Cryptococcal AntigenClinical Infectious Diseases, 2008
- Serologic Evidence for Reactivation of Cryptococcosis in Solid-Organ Transplant RecipientsClinical and Vaccine Immunology, 2007
- Cryptococcus neoformansin Organ Transplant Recipients: Impact of Calcineurin‐Inhibitor Agents on MortalityThe Journal of Infectious Diseases, 2007
- Determinants of Disease Presentation and Outcome during Cryptococcosis: The CryptoA/D StudyPLoS Medicine, 2007
- Spread ofCryptococcus gattiiin British Columbia, Canada, and Detection in the Pacific Northwest, USAEmerging Infectious Diseases, 2007