Epidemiology of Small Bowel Carcinoids in a Defined Population
- 17 March 2010
- journal article
- research article
- Published by Wiley in World Journal of Surgery
- Vol. 34 (7), 1500-1505
- https://doi.org/10.1007/s00268-010-0519-z
Abstract
This retrospective study describes the epidemiology of small bowel carcinoids in a geographically defined population, with no other selection bias. All patients (n = 145) resident in Jönköping County when diagnosed with carcinoid in the jejunum or ileum from 1960 to 2005 were included. Medical records were reviewed in detail, and tumor specimens were histopathologically and immunohistochemically reexamined when required (n = 44). The annual age-adjusted incidence of small bowel carcinoids was 1.12 (95% confidence interval 0.95–1.31) per 100,000 persons. Median age at diagnosis was 69 years. The predominating presenting symptom was uncharacteristic abdominal pain (50%), whereas a smaller number suffered from typical flushes (13%). Surprisingly, 14% presented with overt gastrointestinal hemorrhage. Most of the patients diagnosed based on their symptoms had metastases at diagnosis (44% regional, 40% distant). Metastasized tumors by definition belong to World Health Organization (WHO) histopathologic group 2; and when reexamined, most (83%) of the localized tumors were also found to belong to WHO group 2. In comparison to previous reports, a higher age-adjusted incidence of small bowel carcinoids was observed, and the patients were clearly older at the time of diagnosis. Even with metastatic disease, the presenting symptoms were usually uncharacteristic, and the carcinoid syndrome was infrequently seen.Keywords
This publication has 30 references indexed in Scilit:
- Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learningCancer, 2009
- One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United StatesJournal of Clinical Oncology, 2008
- Metastatic carcinoid tumor to the ovary: A clinicopathologic analysis of seventeen casesGynecologic Oncology, 2007
- 7201 Carcinoids: Increasing Incidence Overall and Disproportionate Mortality in the ElderlyWorld Journal of Surgery, 2007
- Tumour biology and histopathology of neuroendocrine tumoursBest Practice & Research Clinical Endocrinology & Metabolism, 2007
- CTGF, intestinal stellate cells and carcinoid fibrogenesisWorld Journal of Gastroenterology, 2007
- Management of neuroendocrine tumoursAnnals of Oncology, 2004
- Updated Population-Based Review of Carcinoid TumorsAnnals of Surgery, 2004
- A 5‐decade analysis of 13,715 carcinoid tumorsCancer, 2003
- A Population-Based Study of the Incidence of Malignant Small Bowel Tumours: SEER, 1973–1990International Journal of Epidemiology, 1996