Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression
Top Cited Papers
Open Access
- 16 March 2015
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 16 (3), 6093-6112
- https://doi.org/10.3390/ijms16036093
Abstract
Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than half of the over 65 population. In the past, OA was considered a wear and tear disease, leading to the loss of articular cartilage and joint disability. Nowadays, thanks to advancements in molecular biology, OA is believed to be a very complex multifactorial disease. OA is a degenerative disease characterized by “low-grade inflammation” in cartilage and synovium, resulting in the loss of joint structure and progressive deterioration of cartilage. Although the disease can be dependent on genetic and epigenetic factors, sex, ethnicity, and age (cellular senescence, apoptosis and lubricin), it is also associated with obesity and overweight, dietary factors, sedentary lifestyle and sport injuries. The aim of this review is to highlight how certain behaviors, habits and lifestyles may be involved in the onset and progression of OA and to summarize the principal risk factors involved in the development of this complicated joint disorder.Keywords
This publication has 104 references indexed in Scilit:
- Post-Traumatic Caspase-3 Expression in the Adjacent Areas of Growth Plate Injury Site: A Morphological StudyInternational Journal of Molecular Sciences, 2013
- Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricinExperimental Biology and Medicine, 2011
- Aging and osteoarthritisCurrent Opinion in Rheumatology, 2011
- Applications of Proteomics to Osteoarthritis, a Musculoskeletal Disease Characterized by AgingFrontiers in Physiology, 2011
- Effects of Supplemental Intra-articular Lubricin and Hyaluronic Acid on the Progression of Posttraumatic Arthritis in the Anterior Cruciate Ligament–Deficient Rat KneeThe American Journal of Sports Medicine, 2010
- Knee osteoarthritis in obese women with cardiometabolic clusteringArthritis Care & Research, 2009
- The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationaleBMC Musculoskeletal Disorders, 2009
- Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam StudyAnnals Of The Rheumatic Diseases, 2006
- Leptin: a review of its peripheral actions and interactionsInternational Journal of Obesity, 2002
- Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?Arthritis & Rheumatism, 1996