Effectiveness of Percutaneous Coronary Intervention With Drug‐Eluting Stents Compared With Bypass Surgery in Diabetics With Multivessel Coronary Disease: Comprehensive Systematic Review and Meta‐analysis of Randomized Clinical Data
Open Access
- 22 August 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Heart Association
- Vol. 2 (4), e000354
- https://doi.org/10.1161/jaha.113.000354
Abstract
Background: Controversy persists regarding the optimal revascularization strategy for diabetic patients with multivessel coronary artery disease ( MVD ). Coronary artery bypass grafting ( CABG ) has been compared with percutaneous coronary intervention ( PCI ) using drug‐eluting stents ( DES ) in recent randomized controlled trials ( RCT s). Methods and Results: RCT s comparing PCI with DES versus CABG in diabetic patients with MVD who met inclusion criteria were analyzed (protocol registration No. CRD 42013003693). Primary end point (major adverse cardiac events) was a composite of death, myocardial infarction, and stroke at a mean follow‐up of 4 years. Analyses were performed for each outcome by using risk ratio ( RR ) by fixed‐ and random‐effects models. Four RCTS with 3052 patients met inclusion criteria (1539 PCI versus 1513 CABG ). Incidence of major adverse cardiac events was 22.5% for PCI and 16.8% for CABG ( RR 1.34, 95% CI 1.16 to 1.54, P P =0.01), and MI (10.3% versus 5.9%, RR 1.44, 95% CI 0.79 to 2.6, P =0.23). Stroke risk was significantly lower with DES (2.3% versus 3.8%, RR 0.59, 95% CI 0.39 to 0.90, P =0.01) and subsequent revascularization was several‐fold higher (17.4% versus 8.0%, RR 1.85, 95% CI 1.0 to 3.40, P =0.05). Conclusions: These data demonstrate that CABG in diabetic patients with MVD at low to intermediate surgical risk (defined as EUROSCORE <5) is superior to MVD PCI with DES . CABG decreased overall death, nonfatal myocardial infarction, and repeat revascularization at the expense of an increase in stroke risk.This publication has 35 references indexed in Scilit:
- PROSPERO at one year: an evaluation of its utilitySystematic Reviews, 2013
- Bypass Versus Drug-Eluting Stents at Three Years in SYNTAX Patients With Diabetes Mellitus or Metabolic SyndromeThe Annals of Thoracic Surgery, 2011
- A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 TrialEuropean Heart Journal, 2011
- An international registry of systematic-review protocolsThe Lancet, 2011
- Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery DiseaseThe New England Journal of Medicine, 2009
- Long-Term Safety and Efficacy of Percutaneous Coronary Intervention With Stenting and Coronary Artery Bypass Surgery for Multivessel Coronary Artery DiseaseCirculation, 2008
- Measuring inconsistency in meta-analysesBMJ, 2003
- Quantifying heterogeneity in a meta-analysisStatistics in Medicine, 2002
- How should meta‐regression analyses be undertaken and interpreted?Statistics in Medicine, 2002
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986