Enantioselective C−C Bond Cleavage Creating Chiral Quaternary Carbon Centers
- 20 June 2006
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (15), 3379-3381
- https://doi.org/10.1021/ol061359g
Abstract
A chiral all-carbon benzylic quaternary carbon center is created by the asymmetric intramolecular addition/ring-opening reaction of a boryl-substituted cyclobutanone, which involves enantioselective β-carbon elimination from a symmetrical rhodium cyclobutanolate. The asymmetric reaction was successfully applied to a synthesis of sesquiterpene, (−)-α-herbertenol.Keywords
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