Association of Colorectal Cancer and Prostate Cancer and Impact of Radiation Therapy
Open Access
- 1 July 2009
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 18 (7), 1979-1985
- https://doi.org/10.1158/1055-9965.epi-09-0241
Abstract
To quantify the risk of prostate cancer after colorectal cancer and the risk of colorectal cancer after prostate cancer and to examine the impact of radiation therapy on subsequent cancer risk, we conducted retrospective cohort studies using data from the Surveillance, Epidemiology and End Results program from 1973 to 2005. Standardized incidence ratios (SIR) and 95% confidence intervals (95% CI) were calculated, adjusting for age, ethnicity, and calendar year. The subsequent risk of developing a prostate cancer was significantly elevated in patients diagnosed with colon cancer before age 50 years (SIR, 1.38; 95% CI, 1.18-1.60). The risk of subsequent prostate cancer was decreased for men with rectal cancer who received radiation therapy (SIR, 0.57; 95% CI, 0.52-0.63). Interestingly, this beneficial effect of radiation therapy was only observed in the prostate-specific antigen (PSA) era (1988+). In addition, the prostate cancer cases developed in the radiation therapy group tended to have higher-grade, later-stage tumors, higher PSA levels, and worse survival than those developed in the nonradiation therapy group. In the cohort of prostate cancer patients, the risk of colon cancer was elevated in patients diagnosed with prostate cancer before age 50 years (SIR, 1.51; 95% CI, 1.03-2.20). In conclusion, a diagnosis of colon or prostate cancer in men of younger ages may be an indication for screening of prostate or colon cancer, respectively. The decreased prostate cancer risk in men who received radiation therapy for rectal cancer may be related to the use of PSA for prostate cancer screening or the cure of occult prostate cancer. (Cancer Epidemiol Biomarkers Prev 2009;18(7):1979–85)Keywords
This publication has 27 references indexed in Scilit:
- Radiation Therapy for Prostate Cancer Increases Subsequent Risk of Bladder and Rectal Cancer: A Population Based Cohort StudyJournal of Urology, 2008
- Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of RadiologyCA: A Cancer Journal for Clinicians, 2008
- External beam radiation treatment for rectal cancer is associated with a decrease in subsequent prostate cancer diagnosisCancer, 2008
- Second primary cancers after prostatic irradiation: Ensuring an appropriate analysisCancer, 2006
- Second malignancies after prostate brachytherapy: Incidence of bladder and colorectal cancers in patients with 15 years of potential follow-upInternational Journal of Radiation Oncology*Biology*Physics, 2006
- Cancer incidence after localized therapy for prostate cancerCancer, 2006
- Prostatic irradiation is not associated with any measurable increase in the risk of subsequent rectal cancerInternational Journal of Radiation Oncology*Biology*Physics, 2006
- Occurrence of Second Cancers in Patients Treated With Radiotherapy for Rectal CancerJournal of Clinical Oncology, 2005
- Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidenceGastroenterology, 2003
- Is There an Increased Risk of Second Primaries Following Prostate Irradiation?International Journal of Radiation Oncology*Biology*Physics, 1998