Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review
- 30 March 2010
- journal article
- case report
- Published by Springer Science and Business Media LLC in Rheumatology International
- Vol. 32 (6), 1801-1804
- https://doi.org/10.1007/s00296-010-1429-y
Abstract
We report the case of a 35-years-old renal transplant patient known to have familial Mediterranean fever with serum amyloid A (SAA)-amyloidosis, who presented with his second episode of bilateral pneumonia. As antimicrobials failed to control the first episode of pneumonia and all studies done were non-contributory, we attributed the condition to the highly active Mediterranean fever presumably resistant to colchicine and treated the patient with the interleukin-1 receptor antagonist anakinra: the patient substantially improved by clinical symptoms, chemistry and radiological evidence within no more than 2 days and was discharged in good health after 4 days.Keywords
This publication has 14 references indexed in Scilit:
- Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantationNephrology Dialysis Transplantation, 2008
- The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragmentBlood, 2008
- Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinraAnnals Of The Rheumatic Diseases, 2007
- Anakinra in two adolescent female patients suffering from colchicine-resistant familial Mediterranean fever: effective but riskyEuropean Journal of Clinical Investigation, 2007
- The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean feverEuropean Journal of Pediatrics, 2007
- Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutationsRheumatology, 2006
- Familial Mediterranean feverRheumatology International, 2005
- Diagnostic and treatment concerns in familial Mediterranean feverBest Practice & Research Clinical Rheumatology, 2000
- Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean FeverCell, 1997
- Effect of oral colchicine on T cell subsets, monocytes and concanavalin A‐induced suppressor cell function in asthmatic patientsClinical and Experimental Allergy, 1986