Sedation improves early outcome in severely septic Sprague Dawley rats
Open Access
- 1 January 2009
- journal article
- Published by Springer Science and Business Media LLC in Critical Care
- Vol. 13 (4), R136
- https://doi.org/10.1186/cc8012
Abstract
Sepsis, a systemic inflammatory response to infective etiologies, has a high mortality rate that is linked both to excess cytokine activity and apoptosis of critical immune cells. Dexmedetomidine has recently been shown to improve outcome in a septic cohort of patients when compared to patients randomized to a benzodiazepine-based sedative regimen. We sought to compare the effects of dexmedetomidine and midazolam, at equi-sedative doses, on inflammation and apoptosis in an animal model of severe sepsis.Keywords
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