Lactoferrin-Decorated Cerium Oxide Nanoparticles Prevent Renal Injury and Fibrosis
- 14 May 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Biological Trace Element Research
- Vol. 201 (4), 1837-1845
- https://doi.org/10.1007/s12011-022-03284-6
Abstract
Renal fibrosis is a hallmark feature of chronic kidney diseases (CKDs). However, despite the increased prevalence of renal fibrosis, there is no approved antifibrotic drug for the management of renal fibrosis. Cerium oxide nanoparticles (CONPs) have been demonstrated to possess a number of properties including antioxidant, anti-inflammatory and nephroprotective activity. As the kidneys are rich in lactoferrin (Lf) receptors, we synthesised the lactoferrin-CONP (Lf-CONP) system to be used for active targeting of the kidneys and provide antifibrotic effects of CONPs to the kidneys. We used the unilateral ureteral obstruction (UUO)–induced renal fibrosis model and treated the animals with Lf-CONP to observe the antifibrotic effects of Lf-CONP. Lf-CONP was found to inhibit the progression of renal fibrosis in a superior manner when compared to CONPs alone.Keywords
This publication has 53 references indexed in Scilit:
- Human lactoferrin activates NF‐κB through the Toll‐like receptor 4 pathway while it interferes with the lipopolysaccharide‐stimulated TLR4 signalingThe FEBS Journal, 2010
- Anti‐inflammatory Properties of Cerium Oxide NanoparticlesSmall, 2009
- Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxidesNature Nanotechnology, 2006
- Activation of ERK in renal fibrosis after unilateral ureteral obstruction: Modulation by antioxidantsKidney International, 2005
- Expression and prognostic value of lactoferrin mRNA isoforms in human breast cancerInternational Journal of Cancer, 2004
- Antioxidant Intervention Blunts Renal Injury in Experimental Renovascular DiseaseJournal of the American Society of Nephrology, 2004
- Expression of lactoferrin in the kidney: Implications for innate immunity and iron metabolismKidney International, 2000
- Inhibition of Corneal Fibrosis by Topical Application of Blocking Antibodies to TGF?? in the RabbitCornea, 1997
- Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry, 1979
- Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liverBiochimica et Biophysica Acta (BBA) - General Subjects, 1979