Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature
Open Access
- 1 August 2019
- journal article
- review article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 58 (15), 2207-2211
- https://doi.org/10.2169/internalmedicine.2515-18
Abstract
An 81-year-old woman with rheumatoid arthritis (RA) who had been treated with bucillamine presented with dyspnea. Computed tomography of the chest showed ground-glass opacities and consolidations in both lungs and honeycombing in both basal lung areas. An elevation of the serum Krebs von den Lungen-6 level and hypoxemia were seen. Lymphocytosis with a decreased CD4/CD8 ratio was seen in the bronchoalveolar lavage fluid. A transbronchial lung biopsy specimen showed organizing pneumonia. Based on a diagnosis of bucillamine-induced pneumonitis (BIP) with RA-associated pre-existing interstitial pneumonia, she was successfully treated with the cessation of bucillamine and systemic corticosteroid therapy. The risk factors and prognosis of BIP are discussed.Keywords
This publication has 27 references indexed in Scilit:
- Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control studyBMJ Open, 2013
- Acute exacerbation of interstitial pneumonia associated with collagen vascular diseasesRespiratory Medicine, 2009
- Hepatobiliary and pancreatic: Hypersensitivity pneumonitis induced by penicillamineJournal of Gastroenterology and Hepatology, 2009
- Acute Exacerbation of Chronic Interstitial PneumoniaJournal of Thoracic Imaging, 2007
- Acute interstitial pneumonitis induced by bucillamine in a patient with rheumatoid arthritis.Japanese Journal of Clinical Immunology, 1991
- D-Penicillamine-Induced Severe PneumonitisSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1982
- Relationship of gold and penicillamine therapy to diffuse interstitial lung disease.Annals Of The Rheumatic Diseases, 1981
- Pulmonary eosinophilia caused by penicillamine.Thorax, 1980
- Miliary pulmonary infiltrates and penicillamineThe British Journal of Radiology, 1978
- Diffuse alveolitis as complication of penicillamine treatment for rheumatoid arthritis.BMJ, 1976