Biological and Mechanistic Activities of Xanthorrizol and 4-(1‘,5‘-Dimethylhex-4‘-enyl)-2-methylphenol Isolated from Iostephane heterophylla
- 30 June 2001
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (7), 911-914
- https://doi.org/10.1021/np010076o
Abstract
Xanthorrizol (1) and 4-(1‘,5‘-dimethylhex-4‘-enyl)-2-methylphenol (2) were identified as the principal antimicrobial components of a CH2Cl2−MeOH (1:1) extract derived from Iostephane heterophylla. Compound 2 is a new natural product, but has been synthesized. Both compounds exhibited low level activity (MICs of 16−32 μg/mL) against methicillin-resistant staphylococci and vancomycin-resistant enterococci. They were either inactive or poorly active against Gram-negative bacteria and yeast. Mechanistic studies performed in Escherichia coli imp suggested nonspecific inhibition of DNA, RNA, and protein synthesis by both of these compounds. Compound 1 was tested in an in vivo model; it did not provide protection to mice infected with Staphylococcus aureus.Keywords
This publication has 8 references indexed in Scilit:
- Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aortaLife Sciences, 2000
- Effect of xanthorrhizol, xanthorrhizol glycoside and trachylobanoic acid isolated from cachani complex plants upon the contractile activity of uterine smooth musclePhytotherapy Research, 1999
- Novel Bisabolene Glycoside and Other Constituents from the Roots of the Medicinal PlantIostephane heterophylla(Asteraceae)Natural Product Letters, 1995
- Bisabolenes, polycyclic diterpenoids and other constituents from the roots of Iostephane heterophyllaPhytochemistry, 1993
- THE AGAR DIFFUSION ASSAYPublished by Elsevier BV ,1989
- Medicinal plants of the sierra madre: Comparative study of tarahumara and Mexican market plantsEconomic Botany, 1986
- Structures and synthesis of some new antibacterial sesquiterpenoids from the gorgonian coral Pseudopterogorgia rigidaTetrahedron, 1978
- Xanthorrhizol, ein neues Sesquiterpen aus Curcuma xanthorrhizaZeitschrift für Naturforschung B, 1970