Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves

Abstract

A single oral dosage of furaltadone and nitrofurazone (14.0 mg/kg) to 5 preruminant calves (in a cross‐over trial) revealed mean maximum plasma concentration of 2.5 and 3.5 pg/ml, respectively, at approximately 3 h after administration. The final elimination half‐lives of furaltadone and nitrofurazone were 2.5 and 5 h, respectively. Urinary recovery of these two nitrofurans in 3 calves revealed approximately 2% of the orally administered dose. The renal clearance of the unbound drugs did not differ (for both drugs approximately 0.42 ml/min/kg);furaltadone clearance was strongly related to urine flow.