Giant adrenal myelolipoma and testicular interstitial cell tumor in a man with congenital 21-hydroxylase deficiency

Abstract

The occurrence of a giant myelolipoma of the adrenal gland is reported in a patient with congenital adrenal hyperplasia (21-hydroxylase deficiency). Associated significant findings include a massive proliferation of adrenocortical cells as an integral part of the myelolipoma and a coincidental tumor of the interstitial cells of the testis. The clinical, radiologic, endocrinologic and pathologic features of this case are correlated with a review of the literature. Three additional [human] myelolipomas are reported. Similar lesions have been induced experimentally in rats and provide further evidence suggesting a hyperplastic rather than a neoplastic nature for this complex lesion, at least in its earlier stages.