The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions
- 19 January 2010
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 38 (1), 65-71
- https://doi.org/10.1042/bst0380065
Abstract
The APC/C (anaphase-promoting complex/cyclosome) is an E3 ubiquitin ligase that targets specific substrates for degradation by the 26S proteasome. APC/C activity depends on two cofactors, namely Cdc20 (cell division cycle 20) and Cdh1, which select the appropriate targets for ubiquitination. It is well established that APC/C is a target of the SAC (spindle assembly checkpoint) during mitosis and has critical roles in controlling the protein levels of major regulators of mitosis and DNA replication. In addition, recent studies have suggested new cell-cycle-independent functions of APC/C in non-mitotic cells and specifically in neuronal structure and function. Given the relevant functions of APC/C in cell proliferation and neuronal physiology, modulating APC/C activity may have beneficial effects in the clinic.Keywords
This publication has 48 references indexed in Scilit:
- A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras OncogeneCell, 2009
- Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 BindingDevelopmental Cell, 2009
- BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in InterphaseDevelopmental Cell, 2009
- A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic NeuronsCell, 2009
- Cdk-counteracting phosphatases unlock mitotic exitCurrent Opinion in Cell Biology, 2008
- Emerging cancer therapeutic opportunities by inhibiting mitotic kinasesCurrent Opinion in Pharmacology, 2008
- APC/CCdc20 Controls the Ubiquitin-Mediated Degradation of p21 in PrometaphaseMolecular Cell, 2007
- Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activitiesNature, 2007
- A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancersNature Genetics, 2006
- Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growthNature, 2006