Resistance profile to antimicrobial agents in the main circulating bacteria isolated from acute periodontal and endodontic infections in Latin America (MICROBE- DENT)
Open Access
- 1 November 2018
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Medicine
- Vol. 97 (48), e13158
- https://doi.org/10.1097/md.0000000000013158
Abstract
Background: Antimicrobial resistance is currently considered the main risk to global health. A variety of microbial species have been isolated from endodontic and periodontal infections. However, clinical endodontic and periodontics bacterial isolates have not been sufficiently characterized with regard to their capacity for antibiotic resistance. We aim to assess the existing evidence to estimate the prevalence of the main antimicrobial resistance and multidrug resistant organisms in endodontics and periodontics and to describe their geographic distribution in Latin America. Methods: All types of designs and will be restricted to Latin American studies will be included in this systematic review. MEDLINE, Embase, CINAHL, BVS (LILACS, BBO - bvsalud.org), IBECS (bases.bireme.br), Google Scholar, Cochrane Central Register of Controlled Trials, and Web of Science databases will be searched from 2013 to December 31, 2018 for all types of study designs that report microbial infection in endodontics and periodontics and their resistance and that define the microbiological methods used to identify microorganisms. The selection of articles for inclusion will be performed by 2 reviewers using predefined eligibility criteria. The Cochrane and ROBINS-I risk of bias assessment tools will be used to assess the methodological quality of randomized control trials. The Newcastle-Ottawa scale will be used to assess the quality of methodology in observational studies. The overall quality of evidence will be assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) using the same principles and domains applied in the quality assessment of prognostic studies. The heterogeneity of the findings will be assessed using both the chi(2) test and the I-2 statistic. Sensitivity analysis will be performed by subgroup analyses and meta-regression to investigate the effect of study-level characteristics, such as age, gender, and methodological quality score, whenever possible. Publication bias across studies will be evaluated by visual inspection of the funnel plots and Begg's test for the results covered in 10 or more studies. Results: The evidence derived by this study will inform best practices for patients with endodontic and periodontal problems receiving antimicrobial agents. Conclusion: Successful completion will significantly impact clinical practice and contribute to improved prescribing competency.Keywords
This publication has 13 references indexed in Scilit:
- Antibiotic resistance—the need for global solutionsThe Lancet Infectious Diseases, 2013
- Antibiotic Resistance and Capacity for Biofilm Formation of Different Bacteria Isolated from Endodontic Infections Associated with Root-filled TeethJournal of Endodontics, 2013
- Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistanceClinical Microbiology & Infection, 2012
- Antibiotic resistance is ancientNature, 2011
- Strategies for Improving Antimicrobial Use and the Role of Antimicrobial Stewardship ProgramsClinical Infectious Diseases, 2011
- Analysis of the Antimicrobial Susceptibility of Anaerobic Bacteria Isolated from Endodontic Infections in Brazil during a Period of Nine YearsJournal of Endodontics, 2011
- The microbiology of the acute dental abscessJournal of Medical Microbiology, 2009
- Geographical Differences in Bacteria Detected in Endodontic Infections Using Polymerase Chain ReactionJournal of Endodontics, 2004
- Antibiotic Susceptibility of Bacteria Associated with Endodontic AbscessesJournal of Endodontics, 2003
- Mortality associated with odontogenic infection!British Dental Journal, 2001