Race- and Sex-Related Differences in Retinal Thickness and Foveal Pit Morphology
Top Cited Papers
- 1 January 2011
- journal article
- retina
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Ophthalmology & Visual Science
- Vol. 52 (1), 625-634
- https://doi.org/10.1167/iovs.10-5886
Abstract
Purpose.: To examine sex- and race-associated differences in macular thickness and foveal pit morphology by using spectral-domain optical coherence tomography (SD-OCT). Methods.: One hundred eighty eyes of 90 healthy patients (43 women, 47 men) underwent retinal imaging with spectral-domain OCT. The lateral scale of each macular volume scan was corrected for individual differences in axial length by ocular biometry. From these corrected volumes, Early Treatment Diabetic Retinopathy Study (ETDRS) grids of retinal thickness were generated and compared between the groups. Foveal morphology was measured with previously described algorithms. Results.: Compared with the Caucasians, the Africans and African Americans had reduced central subfield thickness. Central subfield thickness was also reduced in the women compared with the men, although the women also showed significant thinning in parafoveal regions. There was no difference between the sexes in foveal pit morphology; however, the Africans/African Americans had significantly deeper and broader foveal pits than the Caucasians. Conclusions.: Previous studies have reported race- and sex-associated differences in macular thickness, and the inference has been that these differences represent similar anatomic features. However, the data on pit morphology collected in the present study reveal an important and significant variation. Between the sexes, the differences are due to global variability in retinal thickness, whereas the variation in thickness observed between the races appears to be driven by differences in foveal pit morphology. These differences have important implications for the use of SD-OCT in detecting and diagnosing retinal disease.This publication has 42 references indexed in Scilit:
- Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCTAmerican Journal of Ophthalmology, 2010
- COMPARISON OF SPECTRAL/FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY INSTRUMENTS FOR ASSESSMENT OF NORMAL MACULAR THICKNESSRetina, 2010
- RELATIONSHIP BETWEEN PHOTORECEPTOR OUTER SEGMENT LENGTH AND VISUAL ACUITY IN DIABETIC MACULAR EDEMARetina, 2010
- Reconstructing foveal pit morphology from optical coherence tomography imagingBritish Journal of Ophthalmology, 2009
- Racial Differences and Other Risk Factors for Incidence and Progression of Age-Related Macular Degeneration: Salisbury Eye Evaluation (SEE) ProjectInvestigative Ophthalmology & Visual Science, 2008
- Foveal Fine Structure in Retinopathy of Prematurity: An Adaptive Optics Fourier Domain Optical Coherence Tomography StudyInvestigative Ophthalmology & Visual Science, 2008
- Role of Ocular Melanin in Ophthalmic Physiology and Pathology†Photochemistry and Photobiology, 2008
- Intravitreal Triamcinolone plus Sequential Grid Laser versus Triamcinolone or Laser Alone for Treating Diabetic Macular Edema: Six-Month OutcomesYearbook of Ophthalmology, 2008
- Randomized Trial of Peribulbar Triamcinolone Acetonide with and without Focal Photocoagulation for Mild Diabetic Macular Edema: A Pilot StudyOphthalmology, 2007
- Age-related macular degeneration: a perspective on genetic studiesEye, 2007