Juice and Phenolic Fractions of the BerryAristotelia chilensisInhibit LDL Oxidationin Vitroand Protect Human Endothelial Cells against Oxidative Stress
- 9 November 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 50 (26), 7542-7547
- https://doi.org/10.1021/jf025797n
Abstract
Oxidative modification of low-density lipoprotein (LDL) particles is a key event in the development of atherosclerosis. Oxidized LDL induces oxidative stress and modifies gene expression in endothelial cells. Berries constitute a rich dietary source of phenolic antioxidants. We found that the endemic Chilean berry Aristotelia chilensis (ach) has higher phenol content and scores better for total radical-trapping potential and total antioxidant reactivity in in vitro antioxidant capacity tests, when compared to different commercial berries. The juice of ach is also effective in inhibiting copper-induced LDL oxidation. In human endothelial cell cultures, the addition of ach juice significantly protects from hydrogen peroxide-induced intracellular oxidative stress and is dose-dependent. The aqueous, anthocyanin-rich fraction of ach juice accounts for most of ach's antioxidant properties. These results show that ach is a rich source of phenolics with high antioxidant capacity and suggest that it may have antiatherogenic properties. Keywords: Oxidative stress; phenolic antioxidants; LDL oxidation; endothelial cell; Aristotelia chilensisThis publication has 30 references indexed in Scilit:
- AtherosclerosisCell, 2001
- Antioxidant Activity of Plant Extracts Containing Phenolic CompoundsJournal of Agricultural and Food Chemistry, 1999
- Absorption and metabolism of cyanidin 3‐O‐β‐D‐glucoside in ratsFEBS Letters, 1999
- Bioavailability of Red Wine Anthocyanins As Detected in Human UrineJournal of Agricultural and Food Chemistry, 1998
- Red wine and fractionated phenolic compounds prepared from red wine inhibit low density lipoprotein oxidation in vitroAtherosclerosis, 1997
- Polyphenol Content and Total Antioxidant Potential of Selected Italian WinesJournal of Agricultural and Food Chemistry, 1997
- The antioxidant properties of theaflavins and their gallate esters — radical scavengers or metal chelators?FEBS Letters, 1996
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- Dietary Antioxidants and Cardiovascular DiseaseAnnals of the New York Academy of Sciences, 1992
- Wine phenolics—analysis of low molecular weight components by high performance liquid chromatographyJournal of the Science of Food and Agriculture, 1984