Prevalence of GAD65 Antibodies in Lean Subjects with Type 2 Diabetes
- 1 December 2004
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1037 (1), 118-121
- https://doi.org/10.1196/annals.1337.018
Abstract
While type 2 diabetic subjects in developed countries are predom- inantly obese or overweight, those in India are often nonobese or lean. The rea- sons for leanness in these subjects has not been well understood. We assessed the prevalence of pancreatic islet autoimmunity in 83 lean adult subjects (BMI < 18.5 kg/m 2 ) with type 2 diabetes by measuring antibodies to glutamic acid de- carboxylase-65 (GAD Abs). Positivity to GAD Ab was present in 21 (25.3%) subjects. In addition, subjects with GAD Ab positivity were younger and had lower beta cell function (homeostasis model assessment, HOMA) as compared to the GAD Ab-negative group. This suggests that the antibody-positive group could have a slowly progressive form of type 1 diabetes.Keywords
This publication has 9 references indexed in Scilit:
- Autoimmune Diabetes Not Requiring Insulin at Diagnosis (Latent Autoimmune Diabetes of the Adult)Diabetes Care, 2001
- Clinical profile of lean NIDDM in South IndiaDiabetes Research and Clinical Practice, 1997
- UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetesThe Lancet, 1997
- Islet-cell antibodies in malnutrition-related diabetes mellitus from North IndiaDiabetes Research and Clinical Practice, 1996
- Small doses of subcutaneous insulin as a strategy for preventing slowly progressive beta-cell failure in islet cell antibody-positive patients with clinical features of NIDDMDiabetes, 1996
- Small Doses of Subcutaneous Insulin as a Strategy for Preventing Slowly Progressive β-Cell Failure in Islet Cell Antibody—Positive Patients With Clinical Features of NIDDMDiabetes, 1996
- U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive DiseaseDiabetes, 1995
- U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study GroupDiabetes, 1995
- Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 1985