Iron deficiency is a key determinant of health‐related quality of life in patients with chronic heart failure regardless of anaemia status
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Open Access
- 1 October 2013
- journal article
- research article
- Published by Wiley in European Journal of Heart Failure
- Vol. 15 (10), 1164-1172
- https://doi.org/10.1093/eurjhf/hft083
Abstract
Aims To evaluate the effect of iron deficiency (ID) and/or anaemia on health‐related quality of life (HRQoL) in patients with chronic heart failure (CHF). Methods and results We undertook a post‐hoc analysis of a cohort of CHF patients in a single‐centre study evaluating cognitive function. At recruitment, patients provided baseline information and completed the Minnesota Living with Heart Failure questionnaire (MLHFQ) for HRQoL (higher scores reflect worse HRQoL). At the same time, blood samples were taken for serological evaluation. ID was defined as serum ferritin levels P ≤ 0.001). Adjusting for haemoglobin and C‐reactive protein, ID was more pronounced in patients with anaemia compared with those without (P < 0.001). Conclusion In patients with CHF, ID but not anaemia was associated with reduced HRQoL, mostly due to physical factors.Keywords
This publication has 25 references indexed in Scilit:
- Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiencyEuropean Journal of Heart Failure, 2012
- The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF studyEuropean Heart Journal, 2012
- Iron Deficiency in Community-Dwelling US Adults With Self-Reported Heart Failure in the National Health and Nutrition Examination Survey IIICirculation: Heart Failure, 2011
- Myocardial and Systemic Iron Depletion in Heart Failure: Implications for Anemia Accompanying Heart FailureJournal of the American College of Cardiology, 2011
- Iron deficiency: an ominous sign in patients with systolic chronic heart failureEuropean Heart Journal, 2010
- Ferric Carboxymaltose in Patients with Heart Failure and Iron DeficiencyThe New England Journal of Medicine, 2009
- Validación de la versión española del Minnesota Living with Heart Failure QuestionnaireRevista Espanola de Cardiologia, 2008
- Intravenous Iron Reduces NT-Pro-Brain Natriuretic Peptide in Anemic Patients With Chronic Heart Failure and Renal InsufficiencyJournal of the American College of Cardiology, 2007
- KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease: 2007 Update of Hemoglobin TargetAmerican Journal of Kidney Diseases, 2007
- Association of Functional and Health Status Measures in Heart FailureJournal of Cardiac Failure, 2006