Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases
Top Cited Papers
- 22 November 2012
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 367 (21), 2015-2025
- https://doi.org/10.1056/nejmra1009433
Abstract
The author reviews the many proposed mechanisms by which intravenous immune globulin may exert its antiinflammatory and autoimmunity-inhibiting clinical effects. No single mechanism can explain its activity in diseases with diverse pathophysiological pathways.Keywords
This publication has 57 references indexed in Scilit:
- IVIg‐mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1European Journal of Immunology, 2012
- Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of GlucocorticoidsJournal of Biological Chemistry, 2011
- Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's diseaseJournal of Neuroinflammation, 2010
- Clinical applications of intravenous immunoglobulins (IVIg) – beyond immunodeficiencies and neurologyClinical and Experimental Immunology, 2009
- Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathyProceedings of the National Academy of Sciences of the United States of America, 2009
- Molecular mechanisms regulating glucocorticoid sensitivity and resistanceMolecular and Cellular Endocrinology, 2009
- Identification of a receptor required for the anti-inflammatory activity of IVIGProceedings of the National Academy of Sciences of the United States of America, 2008
- Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptakeThe Journal of Experimental Medicine, 2008
- Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG FcScience, 2008
- Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humansNature, 2006