Diagnostic Accuracy of Rim and Segmental MRI Enhancement of Colorectal Hepatic Metastasis After Administration of Mangafodipir Trisodium
- 1 February 2007
- journal article
- clinical trial
- Published by American Roentgen Ray Society in American Journal of Roentgenology
- Vol. 188 (2), W154-W161
- https://doi.org/10.2214/ajr.05.1421
Abstract
OBJECTIVE. The purpose of this study was to determine the diagnostic accuracy of rim and segmental MRI enhancement of hepatic metastasis of colorectal cancer after administration of mangafodipir trisodium (MnDPDP). SUBJECTS AND METHODS. Sixty-one patients with a potentially resectable hepatic metastasis of colorectal cancer consecutively underwent breath-hold T1-weighted MRI in the axial and coronal planes 30 minutes and 24 hours after administration of MnDPDP. For each lesion, the presence or absence of rim enhancement and segmental enhancement 30 minutes and 24 hours after contrast administration was recorded. These features were evaluated separately for lesions 10 mm in diameter or larger and lesions smaller than 10 mm. The nature of each lesion was determined at histopathologic examination (n = 29) and on follow-up imaging (n = 32). RESULTS. Two hundred thirty lesions were identified at MRI: 210 lesions were metastatic, and 20 were benign. Rim enhancement was observed around 22 of 210 (10%) of the metastatic lesions at 30 minutes and 199 of 210 (95%) of metastatic lesions at 24 hours. Rim enhancement at 24 hours had 94.8% (95% CI, 91.8-97.8%) sensitivity, 90.0% (68.3-98.8%) specificity, 99.0% (97.6-100%) positive predictive value, 62.1% (42.3-79.3%) negative predictive value, and 94.3% (91.4-97.3%) diagnostic accuracy for metastasis. Segmental enhancement was infrequently seen (34/210; 16%) at 24 hours but had 100% (89.7-100%) positive predictive value for metastasis. CONCLUSION. Rim and segmental enhancement at MRI 24 hours after MnDPDP administration enabled accurate characterization of hepatic colorectal metastasis. These features may aid in preoperative mapping of hepatic tumor burden and disease distribution in patients with colorectal cancer.Keywords
This publication has 20 references indexed in Scilit:
- Detection of Liver Metastases from Adenocarcinoma of the Colon and Pancreas: Comparison of Mangafodipir Trisodium–Enhanced Liver MRI and Whole-Body FDG PETAmerican Journal of Roentgenology, 2005
- Surgical strategies for colorectal liver metastasesSurgical Oncology, 2004
- Small (≤ 2 cm) Hepatic Lesions in Colorectal Cancer Patients: Detection and Characterization on Mangafodipir Trisodium–Enhanced MRIAmerican Journal of Roentgenology, 2004
- Détection de métastases hépatiques du cancer colorectal sous chimiothérapie: Étude comparative en IRM avec Teslascan® et tomodensitométrie avec injection iodéeJournal de Radiologie, 2004
- Combined 5-Fluorouracil/Systemic Interferon-β Gene Therapy Results in Long-Term Survival in Mice with Established Colorectal Liver MetastasesClinical Cancer Research, 2004
- New Guidelines to Evaluate the Response to Treatment in Solid TumorsJNCI Journal of the National Cancer Institute, 2000
- MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteersActa Radiologica, 1997
- MnDPDP-enhanced MR imaging of the liverActa Radiologica, 1997
- Late results justify resection for multiple hepatic metastases from colorectal cancerBritish Journal of Surgery, 1997
- Determinants of survival in liver resection for colorectal secondariesBritish Journal of Surgery, 1986