Islet amyloid polypeptide: Identification and chromosomal localization of the human gene
- 7 November 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 239 (2), 227-232
- https://doi.org/10.1016/0014-5793(88)80922-0
Abstract
Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.Keywords
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