Investigation of new co‐factors in 49 patients with pyoderma gangrenosum
- 15 July 2011
- journal article
- Published by Wiley in JDDG: Journal der Deutschen Dermatologischen Gesellschaft
- Vol. 10 (4), 251-256
- https://doi.org/10.1111/j.1610-0387.2011.07734.x
Abstract
Background: Pyoderma gangrenosum is a rare, destructive, ulcerative neutrophilic dermatosis of unknown origin that has been investigated insufficiently in clinical studies. According to current textbooks, it is often associated with chronic inflammatory bowel diseases or other autoimmune disorders. Patients and methods: We retrospectively analyzed data from 49 patients with pyoderma gangrenosum. Results: Our results showed that although only 6.1 % of patients had chronic inflammatory bowel disease, 22.4 % patients had a malignancy, 18.4 % had chronic renal insufficiency, and 42.8 % had anemia. A potentially relevant aspect that has received little attention is an association with endocrine diseases in 38.8 % of patients. 28.6 % of patients had diabetes. Given that 32.6 % of patients were obese, a potential association with metabolic syndrome may be considered as a possible new risk factor for pyoderma gangrenosum. Conclusions: The clinical data from the present study are insufficient for drawing any firm conclusions. We did, however, observe an association between pyoderma gangrenosum and certain as yet unreported co-factors, in particular metabolic syndrome. This should be considered in further studies.Keywords
This publication has 17 references indexed in Scilit:
- Psoriasis vulgaris und KomorbiditätenDeutsche Medizinische Wochenschrift (1946), 2010
- Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid ConditionsJournal of Investigative Dermatology, 2010
- Leptin and the skin: a new frontierExperimental Dermatology, 2009
- „TRECID”: TNFα-assoziierte chronisch entzündliche ErkrankungenDeutsche Medizinische Wochenschrift (1946), 2009
- Pyoderma gangrenosum: Clinical presentation and outcome in 18 cases and review of the literatureJDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2007
- Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteriaInternational Journal of Dermatology, 2004
- Pyoderma gangrenosum: a report of 44 cases with follow-upBritish Journal of Dermatology, 1997
- Pyoderma gangrenosum: Classification and managementJournal of the American Academy of Dermatology, 1996
- The Evolution of Pyoderma GangrenosumThe American Journal of Dermatopathology, 1993
- PYODERMA GANGRENOSUM: ASSOCIATIONS REVISITEDInternational Journal of Dermatology, 1992