Canine Atopic Dermatitis: New Targets, New Therapies
Open Access
- 1 August 2004
- journal article
- review article
- Published by Elsevier BV in Journal of Nutrition
- Vol. 134 (8), 2056S-2061S
- https://doi.org/10.1093/jn/134.8.2056s
Abstract
Atopic dermatitis is a common allergic skin disease of complex etiopathogenesis in both humans and dogs. Immediate-type hypersensitivity to environmental allergens that arises as a result of environmental and genetic factors is a major part of the pathogenesis in most but not all patients. Alterations in epidermal barrier function, priming of cutaneous antigen-presenting cells with IgE, intrinsic keratinocyte defects, and even development of autoimmunity are also factors that contribute to the primary disease. Secondary factors, especially infections with Staphylococcus and yeast organisms, strongly influence the course of this skin disease. The relatively recent understanding of the complexities of atopic dermatitis has resulted in changes in diagnostic and therapeutic strategies for the disease. We now know that the best therapeutic approach is to use combinations of multiple modalities individualized for each patient over the course of his or her lifetime.Keywords
This publication has 42 references indexed in Scilit:
- IgE‐reactivity to seven Malassezia speciesAllergy, 2003
- Atopic dermatitisThe Lancet, 2003
- Positive ‘atopy patch tests’ reactions in IgE‐hyperresponsive beagle dogs are dependent upon elevated allergen‐specific IgE serum levels and are associated with IgE‐expressing dendritic cellsVeterinary Dermatology, 2002
- Staphylococcal Toxins Augment Specific IgE Responses by Atopic Patients Exposed to AllergenJournal of Investigative Dermatology, 1999
- Heterogeneity of polyclonal IgE characterized by differential charge, affinity to protein A, and antigenicityJournal of Allergy and Clinical Immunology, 1997
- The genetics of atopyJournal of Allergy and Clinical Immunology, 1994
- Antistaphylococcal antibodies in dogs with recurrent staphylococcal pyodermaVeterinary Immunology and Immunopathology, 1994
- Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.JCI Insight, 1994
- Inability of Short‐duration Treatment with a 5‐Lipoxy‐genase Inhibitor to Reduce Clinical Signs of Canine AtopyVeterinary Dermatology, 1994
- Effects of oral sunflower oil and olive oil on serum and cutaneous fatty acid concentrations in dogsResearch in Veterinary Science, 1992