Coronary and Basilar Artery Ectasia Are Associated
- 1 January 2016
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 47 (1), 224-227
- https://doi.org/10.1161/strokeaha.115.010797
Abstract
Background and Purpose— Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series. Methods— Sixteen stroke patients with IADE were identified among 381 stroke patients and were matched with 16 stroke patients without IADE. The heart and coronary arteries from all patients were examined after a prespecified protocol. Results— Coronary artery ectasia was observed in 8 of the stroke patients with IADE, and in none of the stroke patients without IADE (P=0.008). The diameters of basilar and right coronary arteries were positively correlated (IADE patients, r=0.51; P=0.003 and coronary artery ectasia patients, P=0.006). Conclusions— This autopsy study examining the association of coronary artery ectasia and IADE in stroke patients suggests a common pathogenesis.This publication has 14 references indexed in Scilit:
- Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasiaThe Lancet Neurology, 2015
- Moving Vessel Wall Research Beyond the PlaqueArteriosclerosis, Thrombosis, and Vascular Biology, 2013
- Basilar Artery Diameter Is an Independent Predictor of Incident Cardiovascular EventsArteriosclerosis, Thrombosis, and Vascular Biology, 2013
- Association of Small-Vessel Disease With Dilatative Arteriopathy of the BrainStroke, 2007
- Concurrent dolichoectasia of basilar and coronary arteriesNeurology, 2006
- Concurrent dolichoectasia of basilar and coronary arteriesNeurology, 2005
- Intracranial arterial dolichoectasia is associated with enlarged descending thoracic aortaNeurology, 2004
- Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery diseaseJournal of the American College of Cardiology, 2002
- Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronaropathy”)Journal of the American College of Cardiology, 1999
- The etiology of posterior circulation infarctsNeurology, 1993