Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5
- 1 January 2007
- journal article
- review article
- Published by Informa UK Limited in Autoimmunity
- Vol. 40 (4), 254-259
- https://doi.org/10.1080/08916930701357331
Abstract
Apoptotic cell death and the efficient clearance of dying cells are essential mechanisms to control tissue homeostasis and to eliminate potential autoantigens. Numerous alterations on the surfaces of dying cells define a highly characteristic membrane signature and enable an unequivocal distinction from vital cells. This way, phagocytosis is initiated and signalling events induced which minimize inflammatory reactions. Therefore, the use of proteins interfering with the clearance process may open up new vistas to improve immunization strategies and may help to understand the mechanisms of autoimmune diseases.Keywords
This publication has 42 references indexed in Scilit:
- Leishmaniadisease development depends on the presence of apoptotic promastigotes in the virulent inoculumProceedings of the National Academy of Sciences of the United States of America, 2006
- Involvement of phosphatidylserine, αvβ3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophagesArthritis & Rheumatism, 2006
- Caspase-dependent immunogenicity of doxorubicin-induced tumor cell deathThe Journal of Experimental Medicine, 2005
- Annexin A5 in cardiovascular disease and systemic lupus erythematosusImmunobiology, 2005
- Signals, receptors, and cytokines involved in the immunomodulatory and anti‐inflammatory properties of apoptotic cellsSignal Transduction, 2005
- Cell Surface-expressed Phosphatidylserine and Annexin A5 Open a Novel Portal of Cell EntryPublished by Elsevier BV ,2004
- Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction SignalCell, 2003
- Disposal of dying cells: A balancing act between infection and autoimmunityArthritis & Rheumatism, 2003
- Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.JCI Insight, 1998
- Sub-domain structure of lipid-bound annexin-V resolved by electron image analysisJournal of Molecular Biology, 1991