Micro‐RNA‐375 inhibits lung surfactant secretion by altering cytoskeleton reorganization
Open Access
- 14 December 2009
- journal article
- research article
- Published by Wiley in IUBMB Life
- Vol. 62 (1), 78-83
- https://doi.org/10.1002/iub.286
Abstract
Lung surfactant is secreted via exocytosis of lamellar bodies from alveolar epithelial type II cells. Whether micro‐RNAs regulate lung surfactant secretion is unknown. Micro‐RNA‐375 (miR‐375) has been shown to be involved in insulin secretion. In this article, we report that the overexpression of miR‐375 inhibited lung surfactant secretion. However, miR‐125a, miR‐30a, miR‐1, miR‐382 and miR‐101 did not influence lung surfactant secretion. miR‐375 had no effects on surfactant synthesis or the formation of lamellar bodies. However, miR‐375 did abolish the lung surfactant secretagogue‐induced disassembly and reassembly of cytoskeleton. Our results suggest that miR‐375 regulates surfactant secretion via the reorganization of cytoskeleton. © 2009 IUBMB IUBMB Life, 62(1):78–83, 2010Keywords
This publication has 18 references indexed in Scilit:
- Physical and Functional Interactions of SNAP-23 with Annexin A2American Journal of Respiratory Cell and Molecular Biology, 2007
- Regulation of surfactant secretion in alveolar type II cellsAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
- Illuminating the silence: understanding the structure and function of small RNAsNature Reviews Molecular Cell Biology, 2007
- Oncomirs — microRNAs with a role in cancerNature Reviews Cancer, 2006
- A pancreatic islet-specific microRNA regulates insulin secretionNature, 2004
- Syntaxin 2 and SNAP-23 Are Required for Regulated Surfactant SecretionBiochemistry, 2004
- Characterization of α-Soluble N-Ethylmaleimide–Sensitive Fusion Attachment Protein in Alveolar Type II CellsAmerican Journal of Respiratory Cell and Molecular Biology, 2003
- V-1, a Protein Expressed Transiently during Murine Cerebellar Development, Regulates Actin Polymerization via Interaction with Capping ProteinPublished by Elsevier BV ,2003
- Lung annexin II promotes fusion of isolated lamellar bodies with liposomesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1995
- Effects of CapZ, an actin-capping protein of muscle, on the polymerization of actinBiochemistry, 1989