Three genes determine the carboxin sensitivity of mitochondrial succinate oxidation inAspergillus nidulans

Abstract

Partially dominant mutations to carboxin resistance occur in three, freely recombining, nuclear genes in Aspergillus nidulans. Mutations at all three loci reduce carboxin inhibition of succinate dehydrogenase (EC 1.3.99.1), succinate-cytochrome c reductase (EC 1.3.99.1) and succinate oxidase (EC 1.3.99.1) in mitochondrial preparations. It is therefore probable that the ability of carboxin to prevent growth of A. nidulans is a direct consequence of its ability to prevent succinate oxidation.