Effect of growth hormone on short normal children.
- 5 September 1987
- Vol. 295 (6598), 573-577
- https://doi.org/10.1136/bmj.295.6598.573
Abstract
The growth of 26 short normal prepubertal children (mean age 8.4, height velocity standard deviation score for chronological age between +0.4 and -0.8) was studied for two years. Sixteen children were treated with somatrem (methionyl growth hormone) during the second year, and the remaining 10 children served as controls. During one year of treatment the height velocity standard deviation score for chronological age increased from the pretreatment mean of -0.44 (SD 0.33) to +2.20 (1.03). These values represented a change in height velocity from a pretreatment mean of 5.3 cm/year (range 4.6-6.9) to 7.4 cm/year (range 5.7-9.9). In the control group the height velocity standard deviation score was unchanged. Bone age advanced by 0.75 (0.33) years in the treated group compared with 0.70 (0.18) years in the control group. There was a significant increase in the height standard deviation score for bone age (0.63 (0.55] in the treated group. Multiple regression analysis of predictive factors contributing to the change in height velocity standard deviation score over the first year of treatment showed that the dose of growth hormone and pretreatment height velocity standard deviation score were important, together yielding a regression correlation coefficient of 0.80. The only metabolic side effect of treatment was an increase in fasting insulin concentration, which may be an important mediator of the anabolic effects of growth hormone. Treatment had no effect on thyroid function, blood pressure, or glucose tolerance. At the end of the treatment year seven of the 16 treated children had developed antibodies to growth hormone, but they were present in low titre with low binding capacity and in no child was growth attenuated. Biosynthetic growth hormone improved the height velocity of children growing along or parallel to the third height centile, but the effects on height prognosis need to be assessed over a longer period.This publication has 46 references indexed in Scilit:
- TALL STATURE: A CLINICAL, ENDOCRINOLOGICAL AND RADIOLOGICAL STUDYClinical Endocrinology, 1986
- Growth Response to Human Growth Hormone Treatment in Children with Partial and Total Growth Hormone DeficiencyActa Paediatrica, 1986
- Clinical Experience of Somatrem: UK Preliminary ReportActa Paediatrica, 1986
- MONOCLONAL ANTIBODY-MEDIATED ENHANCEMENT OF GROWTH HORMONE ACTIVITY IN VIVOJournal of Endocrinology, 1985
- Report of the Conference on Uses and Possible Abuses of Biosynthetic Human Growth HormoneNew England Journal of Medicine, 1984
- Prospective clinical trial of human growth hormone in short children without growth hormone deficiencyThe Journal of Pediatrics, 1984
- The Dosage Dependency of Growth and Maturity in Growth Hormone Deficiency Treated with Human Growth HormoneActa Paediatrica, 1984
- Insulin-like Growth Factors I and II, Prolactin, and Insulin in 19 Growth Hormone-Deficient Children with Excessive, Normal, or Decreased Longitudinal Growth after Operation for CraniopharyngiomaNew England Journal of Medicine, 1983
- Growth Hormone Treatment for Short StatureNew England Journal of Medicine, 1983
- Effect of Human Growth Hormone Treatment for 1 to 7 Years on Growth of 100 Children, with Growth Hormone Deficiency, Low Birthweight, Inherited Smallness, Turner's Syndrome, and Other ComplaintsArchives of Disease in Childhood, 1971