Dietary Fatty Acids and the 10-Year Incidence of Age-Related Macular Degeneration

Abstract
The potential influence of diet on the risk or the progression of age-related macular degeneration (AMD), a major cause of blindness,1has gained increasing interest. Management of AMD has been influenced by evidence from the Age-Related Eye Disease Study (AREDS) that a high-dose supplement of zinc and antioxidant vitamins (ascorbic acid [vitamin C], vitamin E, and beta carotene) slowed AMD progression by about 25% in relatively advanced early AMD.2A new AREDS trial is assessing an alternative supplement that includes long-chain ω-3 polyunsaturated fatty acids (PUFAs) and replaces beta carotene with lutein.3