Thyroid axis dysfunction in patients with Prader‐Willi syndrome during the first 2 years of life
- 19 June 2010
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 73 (4), 546-550
- https://doi.org/10.1111/j.1365-2265.2010.03840.x
Abstract
P>Introduction Prader-Willi syndrome (PWS) is a genetic disorder caused by the loss of expression of paternally transcribed genes in a highly imprinted region of chromosome 15q11-13. The clinical phenotype has been well characterized, mostly related to hypothalamic dysfunction. Even though central hypothyroidism has been documented in 20-30% of patients with PWS, thyroid function during the first 2 years of life has not been clearly defined. Objective To evaluate hypothalamic-pituitary-thyroid function in infant PWS patients. Study design Eighteen patients with PWS, aged 0 center dot 16-2 years, were included in a prospective study. PWS diagnosis was based on clinical features and molecular analysis. Serum total (T) T4, free (F) T4, T3 and thyroid-stimulating hormone (TSH) were evaluated in the patients with PWS included in the study. Serum hormone values were compared to those of a large reference population of the same age. Results In 13 of 18 patients with PWS (72 center dot 2%), serum TT4 and/or FT4 levels were below the 2 center dot 5th percentile of the reference population, while in only one PWS patient serum T3 was below this cut-off. Conclusion The results of this study suggest that transient or definitive thyrotropin-releasing hormone (TRH)-TSH thyroid axis dysfunction may frequently be present in infant PWS patients. Paediatricians should be aware of this dysfunction in this critical period of thyroid hormone action on neurological development.This publication has 27 references indexed in Scilit:
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