Nonplasmacytoid, High IFN-α–Producing, Bone Marrow Dendritic Cells
Open Access
- 15 April 2012
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 188 (8), 3774-3783
- https://doi.org/10.4049/jimmunol.1101365
Abstract
Plasmacytoid dendritic cells (pDC) are the producers of type I IFNs in response to TLR9 ligands. However, we have found that when bone marrow is depleted of pDC, the IFN-α produced in response to TLR9 ligands is not fully removed. We assign the source of this non-pDC IFN-α as a newly described DC type. It displays the high IFN-α producing activity of pDC but to a more limited range of viruses. Unlike pDC, the novel DC display high T cell stimulation capacity. Moreover, unlike mouse pDC, they are matured with GM-CSF and are less prone to apoptosis upon activation stimuli, including viruses. We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-α production and high T cell stimulatory capacity.Keywords
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