Pancreatitis in Systemic Lupus Erythematosus: Frequency and Associated Factors — A Review of the Hopkins Lupus Cohort
- 23 December 2009
- journal article
- review article
- Published by The Journal of Rheumatology in The Journal of Rheumatology
- Vol. 37 (2), 341-345
- https://doi.org/10.3899/jrheum.090829
Abstract
Objective.Pancreatitis is a rare but potentially life-threatening complication of systemic lupus erythematosus (SLE). Vasculitis of the gastrointestinal tract is the most commonly proposed mechanism. We determined the frequency of SLE-related pancreatitis in the Hopkins Lupus Cohort.Methods.A large prospective cohort of 1811 patients with SLE was reviewed and clinical and laboratory measures of SLE patients who developed pancreatitis were compared to patients who did not develop pancreatitis.Results.Four percent of patients with SLE had pancreatitis due to SLE. The best multivariate model of clinical and laboratory associations included hypertriglyceridemia, psychosis, pleurisy, gastritis, and anemia.Conclusion.Hypertriglyceridemia appears to be a strong associate of pancreatitis in SLE, but antiphospholipid antibodies are not. SLE patients with psychosis and pleurisy are at increased risk for pancreatitis.Keywords
This publication has 15 references indexed in Scilit:
- Abdominal manifestations in childhood-onset systemic lupus erythematosusAnnals Of The Rheumatic Diseases, 2006
- Chronic Calcifying Pancreatitis and Systemic Lupus ErythematousPancreas, 2005
- Leukoencephalopathy and chronic pancreatitis as concomitant manifestations of systemic lupus erythematosus related to anticardiolipin antibodiesRheumatology International, 2003
- A rare initial manifestation of systemic lupus erythematosus--acute pancreatitis: case report and review of the literature.The Journal of the American Board of Family Medicine, 2003
- Classification and definition of major flares in SLE clinical trialsLupus, 1999
- Successful treatment of gastrointestinal vasculitis due to systemic lupus erythematosus with intravenous pulse cyclophosphamide: a clinical case report and review of the literatureRheumatology, 1998
- Acute pancreatitis related to anticardiolipin antibodies in lupus patients visiting an emergency departmentThe American Journal of Emergency Medicine, 1993
- Pancreatitis in systemic lupus erythematosusArthritis & Rheumatism, 1982
- Acute Pancreatitis in Systemic Lupus ErythematosusMedicine, 1982
- Pancreatitis in systemic lupus erythematosus--a case report and review of the literaturePublished by Oxford University Press (OUP) ,1980