Accelerated versus conventional corneal collagen crosslinking
Top Cited Papers
- 1 June 2014
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Cataract & Refractive Surgery
- Vol. 40 (6), 1013-1020
- https://doi.org/10.1016/j.jcrs.2013.12.012
Abstract
To compare the outcomes of accelerated corneal collagen crosslinking (CXL) and conventional corneal CXL. Private practice, Tokyo, Japan. Comparative study. Eyes with keratoconus had accelerated CXL (KXL system; 15 minutes riboflavin [Vibex Rapid] presoak; 3 minutes 30 mW/cm2 ultraviolet-A [UVA] light) or conventional CXL (CCL-365 Vario system; 30 minutes riboflavin [Vibex] presoak; 30 minutes 3 mW/cm2 UVA light). The postoperative changes in visual acuity, keratometry readings, morphologic changes in the cornea, demarcation line existence, and corneal biomechanical responses with accelerated CXL and conventional CXL were compared. The follow-up was 1 year. The study enrolled 48 eyes of 39 patients; 30 eyes had accelerated CXL, and 18 eyes had conventional CXL. There were no statistically significant differences in postoperative changes in uncorrected or corrected distance visual acuity or in the manifest refraction spherical equivalent between the 2 procedures. There were also no statistically significant differences in the postoperative changes in the keratometric readings from the Pentacam Scheimpflug device or the corneal biomechanical responses from a dynamic bidirectional applanation device (Ocular Response Analyzer) or a dynamic Scheimpflug analyzer (Corvis ST) between the procedures. Similar morphologic changes and a pronounced demarcation line were apparent in eyes in both groups postoperatively. Accelerated CXL and conventional CXL were both safe and effective. Accelerated CXL, being a fast procedure, appears to be more beneficial for patients and surgeons. No author has a financial or proprietary interest in any material or method mentioned.Keywords
This publication has 17 references indexed in Scilit:
- Corneal collagen crosslinking in progressive keratoconus: Multicenter results from the French National Reference Center for KeratoconusJournal of Cataract & Refractive Surgery, 2011
- Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusisJournal of Cataract & Refractive Surgery, 2007
- Biomechanical evidence of the distribution of cross-links in corneastreated with riboflavin and ultraviolet A lightJournal of Cataract & Refractive Surgery, 2006
- Increased resistance of crosslinked cornea against enzymatic digestionCurrent Eye Research, 2004
- Stress-strain measurements of human and porcine corneas after riboflavin–ultraviolet-A-induced cross-linkingJournal of Cataract & Refractive Surgery, 2003
- Induction of Cross-links in Corneal TissueExperimental Eye Research, 1998
- Lebend-Epikeratophakie und Tiefe Lamelläre Keratoplastik zur Stadiengerechten chirurgischen Behandlung des Keratokonus (KK) I-IIIKlinische Monatsblätter für Augenheilkunde, 1997
- Abnormalities of the Extracellular Matrix in Keratoconus CorneasCornea, 1997
- Lysosomal Enzyme Abnormalities in KeratoconusAmerican Journal of Ophthalmology, 1989
- Increased collagenase and gelatinase activities in keratoconusBiochemical and Biophysical Research Communications, 1982