The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
- 1 January 1987
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 325 (6102), 321-326
- https://doi.org/10.1038/325321a0
Abstract
Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.Keywords
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