Recruitment of PCM1 to the Centrosome by the Cooperative Action of DISC1 and BBS4

Abstract

Recent genetic studies have suggested that centrosomal dysfunction underlies risks for various neuropsychiatric disorders, because variants in some genes that encode centrosomal proteins have been associated with schizophrenia (SZ) and bipolar disorder (BP).^1-4 These genes include pericentriolar material 1 (PCM1) on chromosome 8p22,² one of the reproducible linkage loci for SZ and BP,^5-8 and disrupted-in-schizophrenia 1 (DISC1).^3,4 The centrosome plays a role in organizing microtubules, contributing to cell cycle progression, cell polarization, and ciliogenesis.^9-12 Consequently, the centrosome is required for proper neurodevelopment, especially in the cerebral cortex.^13-17