Clustering of Risk Factors: A Simple Method of Detecting Cardiovascular Disease in Youth
- 1 February 2011
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 127 (2), e312-e318
- https://doi.org/10.1542/peds.2010-1125
Abstract
OBJECTIVE: Cardiovascular risk assessment is an accepted practice in adults and correlates with early changes in carotid structure and function. Its clinical use in pediatrics is less common. We sought to determine whether a simple method of clustering cardiovascular risks could detect early atherosclerotic changes in youth. In addition, we compared risk clustering with the accepted Patholobiological Determinants of Atherosclerosis in Youth score to assess its utility for predicting early vascular disease. PATIENTS AND METHODS: We collected demographic, anthropometric, laboratory, and vascular measures in a cross-sectional study. The study population (n = 474; mean age: 18 years) was divided into low-risk (0–1) or high-risk (≥2) groups on the basis of the number of cardiovascular risk factors present at evaluation. Group differences and vascular outcomes were compared. General linear models were used to compare clustering cardiovascular risks with the Patholobiological Determinants of Atherosclerosis in Youth score. RESULTS: The high-risk group had higher vascular thickness and stiffness compared with the low-risk group (P < .05). Regression models found that clustering cardiovascular risks is associated with abnormal vascular structure and function after adjustment for age, race, and gender. The Patholobiological Determinants of Atherosclerosis in Youth score also is associated with abnormal vascular structure and function but with lower R2 values (P < .05). CONCLUSIONS: Cardiovascular risk clustering is a reliable tool for assessing abnormal vascular function. Its simplicity, compared with the Patholobiological Determinants of Atherosclerosis in Youth score, provides an advantageous tool for the practicing clinician to identify those youth who are at higher risk for early cardiovascular disease.This publication has 28 references indexed in Scilit:
- Standards of Medical Care in Diabetes—2010Diabetes Care, 2010
- Influence of Duration of Diabetes, Glycemic Control, and Traditional Cardiovascular Risk Factors on Early Atherosclerotic Vascular Changes in Adolescents and Young Adults with Type 2 Diabetes MellitusJournal of Clinical Endocrinology & Metabolism, 2009
- Youth With Obesity and Obesity-Related Type 2 Diabetes Mellitus Demonstrate Abnormalities in Carotid Structure and FunctionCirculation, 2009
- Preventing Heart Disease in the 21st CenturyCirculation, 2008
- Association of Pathobiologic Determinants of Atherosclerosis in Youth Risk Score and 15-Year Change in Risk Score With Carotid Artery Intima–Media Thickness in Young Adults (from the Cardiovascular Risk in Young Finns Study)The American Journal of Cardiology, 2007
- Major Coronary Risk Factors and Death from Coronary Heart Disease: Baseline and Follow-up Mortality Data from the Second National Health and Nutrition Examination Survey (NHANES II)American Journal of Preventive Medicine, 2005
- The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and AdolescentsPEDIATRICS, 2004
- Biochemical assessment of sympathetic activity and prejunctional modulation of noradrenaline release in humansJournal of Hypertension, 1996
- Contributions of the framingham study to the conquest of coronary artery diseaseThe American Journal of Cardiology, 1988
- Relation of Serum Lipoprotein Levels and Systolic Blood Pressure to Early AtherosclerosisThe New England Journal of Medicine, 1986