Amyotrophic Lateral Sclerosis
- 31 May 2001
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 344 (22), 1688-1700
- https://doi.org/10.1056/nejm200105313442207
Abstract
Charcot described amyotrophic lateral sclerosis (ALS) in 1874. Despite progress, this creeping paralysis, known colloquially as Lou Gehrig's disease, is still not visibly affected by available therapies. However, advances in genetics have accelerated the pace of ALS research in the past decade, promising more effective treatment.Definition of the DiseaseALS has two meanings. In one sense, it refers to several adult-onset conditions characterized by progressive degeneration of motor neurons (Figure 1). In the United Kingdom, the term motor neuron disease is used for these disorders. In the second sense, ALS refers to one specific form of motor neuron disease . . .Keywords
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