Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity
- 31 January 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Applied Physiology
- Vol. 106 (1), 51-59
- https://doi.org/10.1007/s00421-009-0988-7
Abstract
The effect of two running sessions completed within a 12-h period on hemolysis, inflammation, and hepcidin activity in endurance athletes was investigated. Ten males completed two experimental trials in a randomized, counterbalanced order. The two trials included (a) a one-running-session trial (T1) including 10 × 1 km interval repeats (90% peak \( \dot{V}{\text{O}}_{2} \) velocity), and (b) a two-running-session trial (T2), comprising a continuous 10-km run (70% peak \( \dot{V}{\text{O}}_{2} \) velocity), and a 10 × 1 km interval run (90% peak \( \dot{V}{\text{O}}_{2} \) velocity) completed 12 h later. Interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, and hepcidin were assessed post-exercise. After the T1 and T2 interval runs, free Hb was significantly increased and Hp significantly decreased (p ≤ 0.05), with a cumulative effect shown in T2 after the second run (p ≤ 0.05). The IL-6, serum iron, ferritin, and hepcidin activity were increased after each running session (p ≤ 0.05), with no cumulative effect in T2. In conclusion, a cumulative effect of two running sessions on hemolysis was shown, but no similar effect with inflammation and hepcidin activity was evident.
Keywords
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