Total Synthesis of Dolabelide D
- 9 February 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (9), 2796-2797
- https://doi.org/10.1021/ja058692k
Abstract
The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation−crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.Keywords
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